Objective: To observe the effect of mango leaf extract (MLE) on acute alcoholic liver injury in mice. Method: Sixty mice were randomly divided into control group

model group

positive drug group(Hugan tablet 1.5 g·kg-1)

MLE high

middle and low-dose(15.0

5.0

2.5 g·kg-1)group

10 each group. Acute liver injury model was induced by 50% alcohol given by gavage. The levels of alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

triglycerides(TG) in the serum and malondialdehyde(MDA)

glutathione(GSH)

total superoxide dismutase (T-SOD) in the liver tissue were measured. Liver index was calculated and pathological changes of the liver tissue were observed under optical microscope. Result: Compared with model group

the serum TG in MLE high

middle and low dose group significantly lowered (P<0.05);the serum ALT

AST in MLE high

middle dose group significantly lowered (P<0.05);T-SOD activity in MLE high dose group rose obviously (P<0.05);GSH levels of liver tissue in MLE high and middle dose group rose obviously (P<0.05);MDA content in liver tissue in MLE high

middle and low dose group lowered obviously (P<0.05);the liver pathological score of MLE high

middle and low dose group lowered significantly (P<0.05). Conclusion: MLE has a protective effect on acute liver injury induced by alcohol in mice

which may be related to its anti-lipid peroxidation.