Objective: To study the effect of Scutellaria barbata polysaccharide on the fluidity of erythrocyte membrane and its mechanism of red cell immune regulation. Method: Fourty eight mice were randomly divided into six groups:normal control group

model control group

Astragalus polysaccharide group (100 mg·kg-1)

S. barbata polysaccharide Dou low

middle

and high dose group (50

100

200 mg·kg-1).The membrane fluidity of erythrocytes in tumor-bearing mice was determined by fluorescence spectrophotometry;the erythrocyte membrane Ca2+

Mg2+-ATPase activity sialic acid (SA) content

antioxidant enzymes activity were detected by UV spectrophotometer. Result: Compared with the modle group

S. barbata polysaccharide low dose

middle dose

high group could obviously improve the fluidity of erythrocyte membrane in S180 tumor-bearing mice(P<0.01

P<0.05)

obviously increase the red cell membrane Ca2+

Mg2+-ATPase activity (P<0.01

P<0.05) and antioxidant enzymes activity(P<0.01

P<0.05); low

middle group increased sialic acid content of red cell membrane surface (P<0.01). Conclusion: S. barbata polysaccharide can increase the fluidity of erythrocyte membrane and enhance the immune function of erythrocyte in S180 tumor-bearing mice

thus it may exert aiti-tumor effect by improving the function of erythrocyte membrane.