Objective: The purpose is to observe the influence of Xiefei Ningxin decoction on vascular endothelial function and inflammatory factor in acute stage of chronic cor pulmonary heart disease (CPHD). Method: Ninety-six cases of CPHD patients were randomly divided into control group (48 cases) and observation group (48 cases) according to digital method. The patients in both groups took supportive treatment

aiming at anti-infection

relieving cough and asthma

eliminating phlegm

diuresis

heart failure

etc. The patients in observation group took Xiefei Ningxin soup

1 dose/day

course treatment 14 days. The blood gas indexes

such as Arterial carbon dioxide partial pressure (PaCO2)

oxygen partial pressure (PaO2) and the blood oxygen saturation (SaO2) were monitored. Pulmonary artery pressure (mPAP) and Tei index were measured

detecting plasma endothelin 1 (ET-1)

nitric oxide (NO)

tumor necrosis factor α(TNF-α) and interleukin 8 (IL-8) level. The cardinal symptom and physical sign score were recorded. Result: The total curative effect of the observation group was 93.75%

superior to 77.08% of the control group (P<0.05). After treatment

PaO2 and SaO2 of patients in observation group were higher than the control group

while PaCO2 is lower than the control group (P<0.01). The mPAP

myocardial performance index

cardinal symptom and physical sign score were lower than control group (P<0.01).ET-1 of observation group was lower than the control group

while the NO level was higher than the control group (P<0.01). The levels of TNF-α and IL-8 of observation group were lower than the control group (P<0.01). Conclusion: Xiefei Ningxin decoction can improve clinical symptoms and physical signs of CPHD patients in acute stage

improving ventilation/air change function and heart function and reducing mPAP. The mechanism may be related to regulating endothelial function

reducing the inflammatory reaction.