Objective: To discuss the clinical efficacy of Self-made Qiangshen Yugan decoction combined with entecavir on treating chronic hepatitis B(CHB) and the influence on(IL-12)

(IL-21). Method: Eighty patients with chronic pyelonephritis were randomly divided into observation group (n=40) and control group (n=40). Patients in the two groups were both treated with entecavir. Self-made Qiangshen Yugan decoction was used in the observation group (one dose per times

24 weeks as one cycle). Levels of serum hepatitis B virus-DNA(HBV-DNA)

Hepatitis B virus markers(HBV-M)

interleukin-12(IL-12) and interleukin-21(IL-21) were tested

liver function and clinical symptoms and signs were also observed. Result: Response rate of observation group (85.0%) was better than the control group (55.0%)(P<0.05);after treatment

HBV-DNA copy number of the observation group was significantly decreased

and lower than the control group (P<0.05). HBV-DNA negative conversion rate of observation was 82.5%

higher than the control group(52.5%)(P<0.05);HBeAg negative rate of observation group was 42.5%

higher than the the control group(20.5%) (P<0.05);aspartate aminotransferase (AST)

alanine aminotransferase (ALT)

glutamyl transpeptidase (GGT) and total bilirubin(TBil) levels of observation group were low than control group (P<0.01)

ALT normalization normalization rate of observation group was 85.0%

higher than the control group(52.5%) (P<0.05);Serum IL-12

IL-21 levels of observation weeks treatment

group were significantly increased and higher than the control group (P<0.05

P<0.01);after 8 weeks treatment

symptom scores of observation group were significantly decreased

at a low level

and was lower than the control group (P<0.01). Conclusion: Self-made Qiangshen Yugan decoction can inhibit HBV replication

reduce HBeAg expression

it also can improve clinical symptoms and signs

promote the recovery of liver function. Its mechanism may be able to increase CHB patients IL-12

IL-21 levels

immune function and it is worth further study.