Objective: The purpose is to study of Xintong Zhuyu decoction on platelet function of unstable angina (UA) patients and the improvement of vascular endothelial function. Method: Seventy-eight cases of UA patients were randomly divided into observation group (39 cases) and control group (39 cases) according to the hospital order. The patients in both groups took general treatment. The patients in control group took clopidogrel tablets

75 mg/time

1 time/day

orally. The patients in observation group took Xintong Zhuyu decoction

0.5 dose/time

2 times/day

conventional water frying. The course treatment for both groups is 8 weeks. Platelet aggregation rate (MPAR)

the plasma platelet α-membrane particle protein (GMP-140)

thromboxane B2(TXB2)

plasma endothelin (ET) levels and hemodynamic indexes will be test before and after the treatment. Result: The total curative effect of observation group was 92.3%

which is higher than 73.52% of the control group (P<0.05). The total curative effect of electrocardiogram of observation group was 82.1%

superior to 61.5% of the control group (P<0.05).After the treatment

the levels of MPAR

GMP-140

TXB2 and ET of observation group were all lower than control group (P<0.01). The improvement of blood rheology indicators

including whole blood viscosity (high shear

low shear)

plasma viscosity

fibrinogen and red cell aggregation index

were better than control group (P<0.01). Conclusion: Xintong Zhuyu decoction can improve platelet aggregation rate

inhibit the formation of blood clots

improve microcirculation status and endothelial function and improve the curative effect and electrocardiogram curative effect. So it is worth promoting in clinical treatment.