Objective: The discussed is to study the control of Naoxintong capsule on adiponectin and endothelial function of coronary heart disease patients with hyperlipidemia. Method: Eighty cases of patients were randomly divided into control group (40 cases) and observation group (40 cases) by digital method. Patients in two groups all took conventional western medicine treatment

atorvastatin

20 mg/time

before sleeping at night orally. In addition

patients in observation group took Naoxintong capsule

1.6 g/time

3 times/day. The courses were all 12 weeks. serum adiponectin (APN)

von Willebrand factor(vWF)

serum nitric oxide (NO)

endothelin 1(ET-1)

thromboxane(TXB2) and 6-ketone-prostaglandin F-(1a)(6-Keto-PGF-1a) were tested before and after treatment

as well as blood lipid level and the examination of the electrocardiogram. Result: The total effective rate of observation group was 95.0%

higher than that of control group 80.0% (P<0.01). The total effective rate of the electrocardiogram effect of observation group was 80.0%

superior to 55.0% in the control group (P<0.01). The levels of cholesterol(TC) and triglycerides(TG) decreased significantly and were lower than the control group (P<0.01). After treatment

the serum APN levels of both groups increased

while obvious increasing occurred in observation group (P<0.01). Serum vWF and TXB2 of two groups decreased and observation group was lower than the control group (P<0.01). NO and 6-Keto-PGF-1a increased in both groups and observation group was higher than the control group(P<0.01).Obvious decreasing of ET-1 took place in both groups and observation group is lower than the control group (P<0.01). Conclusion: Naoxintong capsule can increase APN level of coronary heart disease patients with hyperlipidemia

inhibit inflammatory reaction

by improving the proportion of ET/NO and PGI2/TXA2

decreasing vWF level positive regulating endothelial function

and thus play a role of resistance to atherosclerosis.