Objective: The purpose is to study the curative effect of Yi Kang pill on Graves Disease (GD) and its influences on autoantibodies and adipocytokines. Method: Ninety-two cases of GD patients were randomly divided into control group (46 cases) and observation group (46 cases) according to digital method. Patients in the control group took methimazole

10 mg/time

3 times/day

adjusting the dosage according to the index of thyroid function. On the basis of treatment in the control group

patients in the observation group took Yikang pill

7.5 g/time

2 times/day. Treatment course was 12 weeks. The cardinal symptom and signs of integral change of before and after the treatment of 4

8 and 12 weeks were recorded. Serum thyroid stimulating hormone (TSH)

triiodothyronine (T3)

serum thyroxine (T4)

serum free triiodothyronine (FT3) and serum free thyroxine (FT4) were detected before and after the treatment. Levels of anti-thyroglobulin antibody (TGAb)

thyroid microsomal antibody (TMAb) and thyroperoxidase antibodies (TPOAb) were detected before and after the treatment. Levels of serum free fatty acid (FFA)

adiponectin (APN)

leptin (LP) and resistin (ADSF) were detected before and after the treatment. Result: The total effect of the observation group was 95.6%

superior to 82.6% of the control group (P<0.05). The decline range of cardinal symptom and signs of integral change of observation group was of better than that of control group in eighth weeks and twelfth weeks after the treatment (P<0.01). After treatment

TSH level of observation group was higher than the control group

while levels of T3

T4

FT3 and FT4 were lower than the control group (P<0.05 or P<0.01). TGAb

TPOAb and TMAb of observation group were lower than the control group (P<0.01). Levels of FFA

APN and ASDF were lower than the control group (P<0.01)

while the LP level higher than the control group (P<0.01). Conclusion: Yikang Pill can obviously improve clinical symptoms of GD patient

improving the clinical curative effect. Its mechanism may be related to decrease autoantibodies levels of GD patients and to adjust abnormal immune. Yikang Pill can also regulate adipocytokines level of GD patients

further improving abnormal glucolipid metabolism of GD patients.