Objective: To investigate the links between the ‘blood arthralgia’ theory of Chinese medicine and Oxaliplatin-induced peripheral neurotoxicity

and the effectiveness and severity of Huangqi Guizhi Wuwu decoction on the effect for the treatment of Oxaliplatin-induced peripheral neurotoxicity. Method: Completely searching the clinical researches of Huangqi Guizhi Wuwu decoction for Oxaliplatin-induced peripheral neurotoxicity by computer from CBM

CNKI

Wanfang Data

VIP

Cochrane Library

Medcine

EMbase by the inclusive and exclusive criteria.RevMan 5.0 was used for Metaanalysis. Result: ①Based on the outcomes of 368 patients

16 clinical trials were identified to meet the inclusion criteria. The meta-analyses showed statistically significant differences in favor of Huangqi Guizhi Wuwu decoction compared with mecobalamin for the effectiveness on the effect for the treatment of the peripheral neurotoxicity induced by Oxaliplatin

including the incidence and severity of peripheral neurotoxicity and SNCV

compared with the conventional therapy or mecobalamin.②For all researches the safety analysis found no serious adverse events or adverse reactions (ADR/AE). Conclusion: Huangqi Guizhi Wuwu decoction can prevent Oxaliplatin-induced peripheral neurotoxicity

reduce the incidence of severe peripheral neurotoxicity and alleviate the inhibition of SNCV of oxaliplatin.According to the clinical experimental research

there is no serious adverse events or adverse reactions (ADR/AE)of Huangqi Guizhi Wuwu decoction

so Huangqi Guizhi Wuwu decoction has a certain degree of security for clinical application.