Objective: To optimize water extraction technology and molding process of Tangzhiping granules. Method: With the content of total polysaccharides form Hedysari Radix as index

L9(34) orthogonal test was used to optimize water extraction process of Tangzhiping granules by taking water amount

extraction time and times as factors;With moisture absorption rate

formability

angle of repose and granulation as indexes

single factor tests were adopted to investigate effects of kind and amount of diluents

flavoring agents and wetting agents on molding technology.Angle of repose was determined by fixed funnel method. Result: Optimum water extraction process was as following:extracted 2 times with 10-folds the amount of water

2 h per time.Spray drying process was as following:the relative density of extract 1.05-1.10(60℃)

material temperature 50-60℃

inlet temperature 170℃

outlet temperature 85℃;Ultrafine grinding of Hirudo and Bombyx Batryticatus

volatile oil from Moutan Cortex was prepared β-CD clathrate

with 91% ethanol as wetting agent

powder-diluent(1:0.3)

flavoring agent 2%. Conclusion: Optimized process was reasonable

feasible and applicable to preparation of Tangzhiping granules.