复方缬草牙痛酊中宽叶缬草药渣渗漉工艺的药效学优化研究

袁渊; 鲍家科

doi:10.11653/syfj2013230021

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复方缬草牙痛酊中宽叶缬草药渣渗漉工艺的药效学优化研究

更新时间：2024-01-04

- 复方缬草牙痛酊中宽叶缬草药渣渗漉工艺的药效学优化研究
- Optimization of Percolation Process for Dregs in Compound Toothache Tinctures
- 中国实验方剂学杂志 2013年19卷第23期页码：21-23
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  贵州省中药现代化科技产业研究开发专项项目([2008]5002)
- DOI：10.11653/syfj2013230021
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- 纸质出版日期：2013
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袁渊, 鲍家科. 复方缬草牙痛酊中宽叶缬草药渣渗漉工艺的药效学优化研究[J]. 中国实验方剂学杂志, 2013,19(23):21-23.

YUAN Yuan, BAO Jia-ke. Optimization of Percolation Process for Dregs in Compound Toothache Tinctures[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 21-23.
袁渊, 鲍家科. 复方缬草牙痛酊中宽叶缬草药渣渗漉工艺的药效学优化研究[J]. 中国实验方剂学杂志, 2013,19(23):21-23. DOI： 10.11653/syfj2013230021.

YUAN Yuan, BAO Jia-ke. Optimization of Percolation Process for Dregs in Compound Toothache Tinctures[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 21-23. DOI： 10.11653/syfj2013230021.

摘要

目的: 通过药效学指标优选复方缬草牙痛酊中宽叶缬草药渣的渗漉工艺。方法: 采用小鼠炎症耳廓毛细血管通透性变化模型，比较复方缬草牙痛酊中宽叶缬草药渣的渗漉工艺制成品的药效学指标，通过正交试验考察乙醇体积分数、加醇量、流速、浸泡时间对渗漉工艺的影响。结果: 各因素对宽叶缬草药渣渗漉工艺的影响顺序依次为乙醇体积分数>浸泡时间>加醇量>流速，优选的渗漉工艺为加15倍量75%乙醇浸泡1 h，以3.0 BV·h-1的流速进行渗漉。结论: 通过药效学试验指标优选的渗漉工艺参数稳定可靠，具有实际指导意义。

Abstract

Objective: To optimize percolation process of Valeriana officinalis dregs in compound V. officinalis toothache tinctures with pharmacodynamic indicators. Method: Changes of capillary permeability of mouse ear inflammation model was adopted

pharmacodynamic indicators of percolation process end-product of V. officinalis dregs were compared

effects of ethanol concentration

soaking time

ethanol amount and flow rate on percolation process were investigated by orthogonal test. Result: Pharmacodynamic effects of each factors on percolation process of V. officinalis dregs was in order of ethanol concentration>soaking time>ethanol amount>flow rate

optimum percolation process was as following:soaked 1 h with 15 times the amount of 75% ethanol at 3.0 BV· h-1. Conclusion: Optimized percolation process parameters were stable and reliable through pharmacodynamic tests

they had practical guiding significance.

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