Objective: To optimize machine decoction process of Huanglian Jiedu decoction. Method: With composite score of baicalin

berberine and extractum contents as index

effects of soak time

decoction time and decoction temperature on machine decoction process were optimized by single factor tests and orthogonal test

and compared with traditional decoction process.Contents of index components were determined by HPLC

chromatographic conditions were as follows:YMC-Pack ODS-A column(4.6 mm×250 mm

5 μm)

mobile phase of methanol-0.2% phosphoric acid(47:53)

detection wavelength 250 nm. Result: Optimal machine decoction process was as following:Soaked 10 minutes

decoction time 30 minutes

decoction temperature 105℃;it was better than traditional decoction process. Conclusion: Optimized machine decoction process was reasonable and feasible with controllable evaluation index

it could provide experimental basis for developing of machine decoction process of Chinese medicine decoctions.