Objective: To optimize chitosan flocculant clarification process of Dantao granules and compare with ethanol precipitation method and centrifugation method. Method: With yield of water extract

retention rates of amygdalin and paeoniflorin as comprehensive evaluation index

orthogonal test was adopted to optimize chitosan flocculant clarification process of Dantao granules with chitosan dosage

flocculation liquid temperature and pH of liquid as factors

three clarification processes including ethanal precipitation method

adsorption clarification technique

high-speed centrifugation method were compared with nature sedimentation. Result: Optimized chitosan flocculant clarification process was as following:added 10% liquid volume of 1% chitosan

pH of liquid 6.0

flocculation liquid temperature 50℃;Water extract amount reduced to around 19%

retention rate of amygdalin and paeoniflorin were more than 89%

it was superior to ethanol precipitation method and centrifugation method. Conclusion: Chitosan flocculant clarification could be used as clarification process of Dantao granules

and this optimized technique was reasonable

stable and feasible for industrial production.