Objective: To analysis feasibility of matrix solid-phase dispersion technology for extraction of arctiin and arctigenin from Arctii Fructus. Method: With total extraction amount of arctiin and arctigenin as index

which were determined by HPLC

effects of dispersants

eluents

compaction degree and elution flow rate on extraction rate of active ingredients from Arctii Fructus were investigated by single factor tests

and compared with methanol ultrasonic extraction technology. Result: Optimum matrix solid-phase dispersion technology was as following:with four times the amount of silica gel as dispersants

one hundred times the amount of methanol as eluents

compaction degree moderate extrusion

elution flow rate 40 drops/min. Total extraction ratio of arctiin and arctigenin was up to 7.94%

while it was 7.89% by methanol ultrasonic extraction technology. Conclusion: Matrix solid-phase dispersion method was simple and rapid

it could be used as a new method for extracting main ingredients from Arctii Fructus and provide a reference for extraction of active ingredients from Chinese herbal medicines.