Objective: To investigate in vitro transdermal absorption ability of active ingredients from ginseng extract and ginseng creams. Method: Taking intelligent transdermal absorption instrument

with total saponins and total polysaccharides from ginseng Radix et Rhizoma as indexes

which were determined by UV;Before and after ginseng extract were prepared into ginseng creams

percutaneous absorption capacity changes of index components were investigated by in vitro release test. Result: Transdermal absorption process of total saponins from ginseng creams was in line with the first-order equation

but total polysaccharides from ginseng creams and total saponins and total polysaccharides from ginseng extract were in line with Higuchi release equation;After been prepared into ginseng creams

cumulative release rates of these two ingredients were 82.30% and 67.53%

respectively. Conclusion: ginseng creams had good transdermal ability

it could increase transdermal absorption of effective components and provide a scientific basis for research of other transdermal formulations.