Objective: To determine moisture in Fructus Corni rapidly by Near infrared Spectroscopy. Method: Drying method was used as a reference method to determine the content of moisture in Fructus Corni. In this study

NIR spectra of the powdered Fructus Corni were collected

and the PLS was developed to correlate the spectra and the corresponding values determined by the reference method. Result: The correlation coefficient(R2) of the calibration model of NIR Spectroscopy for moisture was 0.990 52

the root-mean-square error of prediction was 0.297

the prediction mean square error was 0.819. Conclusion: The parameters of the model were also discussed. The overall results show that NIR spectroscopy combined with PLS can be efficiently utilized for rapid and accurate analysis of water in Fructus Corni. Simultaneously

the research can serve as the technical support and the foundation of quantitative analysis of other NIR applications.