Objective: To investigate the effects of flavones of buckwheat (FB) on blood glucose and lipids level

insulin resistance and inflammation factors in Rats with Type 2 Diabetes. Method: Male SD rats were fed high-fat diet after 4 weeks

then injected small dose streptozotocin (STZ) to establish animal models of type 2 diabetes. The rats were divided into 6 groups:normol group

model group

rosiglitazone group(RSg

1 mg·kg-1

ig)

low

middle and high dosage-FB group (100

200

400 mg· kg-1

ig). After 4 weeks' treatment

the levels of FBG

TC

TG

LDL-C

HDL-C

FINS

TNF-α

IL-6

CRP were detected

and insulin sensitive index (ISI) was calculated. Result: Compared with the normol group

levels of serum FBG

TC

TG

LDL-C

FINS

TNF-α

IL-6 and CRP in model group were increased(P<0.01)

but the levels of HDL-C and ISI were decreased significantly(P<0.01). In FB groups

levels of FBG

TC

TG

LDL-C

FINS

TNF-α

IL-6 and CRP were reduced compared with model group(P <0.01

P <0.05)

while HDL-C and ISI were increased in a dose-dependent manner. Conclusion: FB can effectively improve glucose and lipid disorders

improve insulin resistance possibly by decreasing the serum levels of inflammatory cytokines such as TNF-α

IL-6 and CRP of type2 diabetes mellitus rats.