Objective: To study the effect of Xingnao Yizhi capsule on learning and memorizing consolidation of dysmnesia mice induced by scopolamine hydrobromide. Method: Sixty mice were divide into normal control group

model group

Huperzine-A group(0.05 mg· kg-1 )

Xingnao Yizhi capsule of high dose group

middle dose group and low dose group(179.2

89.6

44.8 mg· kg-1).After the intragastric administration twice a day respectively for 15 days

the learning and memory consolidation of dysmnesia model was induced by scopolamine hydrobromide intraperitoneal injection(5 mg· kg-1). Learning and memory function of various group rats were assessed with step-through test and step-down test;The content of malondiadehyde(MDA)

activity of superoxide dismutase(SOD) in brain tissue were detected. Result: Compared with model group

Xingnao Yizhi capsule(179.2 mg· kg-1)prolonged the latency periods of memory and significantly reduced the error times within 5 mins in dysmnesia groups (P<0.05)

increased the activity of SOD and decreased the content of MDA in brain tissue (P<0.05). Conclusion: Xingnao Yizhi capsule has protective effects on learning and memorizing consolidation of dysmnesia mice induced by scopolamine hydrobromide.