狼疮Ⅰ号方治疗系统性红斑狼疮37例

王福祖; 马辉中; 周春言; 星媛

doi:10.11653/syfj2013230278

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狼疮Ⅰ号方治疗系统性红斑狼疮37例

更新时间：2024-01-04

- 狼疮Ⅰ号方治疗系统性红斑狼疮37例
- 37 Cases of Lupus 1 Number Decoction in the Treatment of Systemic Lupus Erythematosus
- 中国实验方剂学杂志 2013年19卷第23期页码：278-281
- 作者机构：
- 作者简介：
- 基金信息：
  
  青海省科技计划项目(20105407)
- DOI：10.11653/syfj2013230278
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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王福祖, 马辉中, 周春言, 等. 狼疮Ⅰ号方治疗系统性红斑狼疮37例[J]. 中国实验方剂学杂志, 2013,19(23):278-281.

WANG Fu-zu, MA Hui-zhong, ZHOU Chun-yan, et al. 37 Cases of Lupus 1 Number Decoction in the Treatment of Systemic Lupus Erythematosus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 278-281.
王福祖, 马辉中, 周春言, 等. 狼疮Ⅰ号方治疗系统性红斑狼疮37例[J]. 中国实验方剂学杂志, 2013,19(23):278-281. DOI： 10.11653/syfj2013230278.

WANG Fu-zu, MA Hui-zhong, ZHOU Chun-yan, et al. 37 Cases of Lupus 1 Number Decoction in the Treatment of Systemic Lupus Erythematosus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(23): 278-281. DOI： 10.11653/syfj2013230278.

摘要

目的: 探讨狼疮I号方对系统性红斑狼疮（SLE）活动期患者疾病活动的影响。方法: 将74例患者随机按数字法分为观察组和对照组各37例。两组均给予常规激素治疗，并给予必要的对症、支持处理。观察组加用狼疮I号方，1剂/d，常规水煎分2次服用。疗程4个月。记录面部红斑、关节疼痛、发热等主症状评分，记录激素用量及系统性红斑狼疮疾病活动度评分（SLEDAI）评分，检测治疗前后血清IL-10，IL-12，β-抑制蛋白质-1（β-arrestinl）及血栓调节蛋白（sTM）水平。结果: 观察组疾病疗效总有效率达100%，优于对照组的83.8%（P<0.05）;治疗后2个月，两组激素用量均较治疗前降低（P<0.01），治疗后4个月，观察组激素用量少于对照组（P<0.01），治疗后观察组激素撤减量多于对照组（P<0.05）;治疗后观察组面部红斑、关节疼痛、发热等症状评分均低于对照组（P<0.01）;治疗后观察组血清IL-10明前下降，并低于对照组（P<0.01），观察组血清IL-12水平升高，并高于对照组（P<0.01）;治疗后观察组血清β-arrestinl水平高于对照组（P<0.01），观察组血清sTM水平低于对照组（P<0.01）。结论: 狼疮I号方能有效控制SLE患者病情活动，协助患者激素的撤减，提高了临床疗效。

Abstract

Objective: The effects of Lupus 1 number decoction on patients with systemic lupus erythematosus (SLE). Method: Seventy-four patients were randomly divided into observation group (n=37) and control group(n=37). Both groups were given conventional hormone and necessary management. Homemade Lupus 1 number decoction was added to observation group

1 dose each day

conventional decocting with water for 2 times

for 4 months. The main symptom scores of facial erythema

arthralgia

fever were recorded. Dosage of hormone and Systemic Lupus Erythematosus Disease Activity(SLEDAI) scores were recorded. Serum IL-10

serum IL-12

β-arrestinl and sTM level pretherapy and post-treatment were detected. Result: The total effective rate of observation group(100% ) was superior to control group(83.8% ) (P<0.05);after the treatment for 2 months

dosage of hormone of both groups were lower than before(P<0.01);after treatment for 4 months

dosage of hormone of observation group was lower than control group(P<0.01);Observation group of hormone withdrawal reduction than the control group after treatmen(P<0.05);after treatment

the main symptom scores of facial erythema

arthralgia

fever of observation group was lower than control group(P<0.01);after treatment the level of serum IL-10 of observation group has dramatic decline and was lower than control group (P<0.01);after treatment the level of serum IL-12 of observation group was risen and higher than control group(P<0.01);β-arrestinl of observation group was higher than control group (P<0.01);sTM level of observation group was lower than control group(P<0.01). Conclusion: Lupus1 number decoction could effective control the disease activity of patients with SLE

assist the hormone withdrawal of patients and improve the clinical curative effect.

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