穗花杉双黄酮自微乳化给药系统的制备及体外评价

任秋霞; 王亚男; 曲新艳; 郑冰清; 洪婷; 周喆

doi:10.11653/syfj2013240005

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穗花杉双黄酮自微乳化给药系统的制备及体外评价

更新时间：2024-01-04

- 穗花杉双黄酮自微乳化给药系统的制备及体外评价
- Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Amentoflavone
- 中国实验方剂学杂志 2013年19卷第24期页码：5-9
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81172981）
- DOI：10.11653/syfj2013240005
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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任秋霞, 王亚男, 曲新艳, 等. 穗花杉双黄酮自微乳化给药系统的制备及体外评价[J]. 中国实验方剂学杂志, 2013,19(24):5-9.

REN Qiu-xia, WANG Ya-nan, QU Xin-yan, et al. Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Amentoflavone[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 5-9.
任秋霞, 王亚男, 曲新艳, 等. 穗花杉双黄酮自微乳化给药系统的制备及体外评价[J]. 中国实验方剂学杂志, 2013,19(24):5-9. DOI： 10.11653/syfj2013240005.

REN Qiu-xia, WANG Ya-nan, QU Xin-yan, et al. Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Amentoflavone[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 5-9. DOI： 10.11653/syfj2013240005.

摘要

目的：制备穗花杉双黄酮自微乳化给药系统并对其进行质量评价。方法：通过溶解度试验、处方配伍试验及绘制伪三元相图筛选辅料种类及用量，通过比较不同处方自微乳外观、粒径及乳化时间优选处方工艺，确定穗花杉双黄酮自微乳载药量并评价其体外释放情况和稳定性。结果：穗花杉双黄酮自微乳最佳处方为m穗花杉双黄酮:m聚氧乙烯蓖麻油:m油酸乙酯:m1，2-丙二醇=5.0:47.5:19.0:28.5，乳滴呈圆球性，粒径（15.37±0.09） nm，Zeta电位（-17.1±0.24） mV，在不同pH介质中自微乳制剂均能快速完全释放药物。结论：穗花杉双黄酮自微乳可显著提高穗花杉双黄酮的体外溶出度，且制备工艺简单、性质稳定。

Abstract

Objective: To develop a self-microemulsifying drug delivery system (SMEDDS) for amentoflavone (AMF) and evaluate its quality. Method: The amount and type of excipients was screened by solubility test

compatibility of oil and surfactant and pseudo-ternary phase diagram

formulation technology of AMF-SMEDDS was optimized by comparing appearance

particle size

self-microemulsifying time and drug loading of different prescriptions

then physicochemical characteristics

in vitro release and stability of AMF-SMEDDS were determined. Result: The best prescription of AMF-SMEDDS was as following:mAMF:mcremophor EL-35:methyl oleate:m1

2-propanediol(5.0:47.5:19.0:28.5);After being diluted with water

AMF-SMEDDS consisted of small spherical droplets with the mean particle size of (15.37±0.09) nm and Zeta potential of (-17.1±0.24) mV

microemulsion could quickly complete release of AMF at different pH medium. Conclusion: AMF-SMEDDS could significantly improve in vitro dissolution of AMF

and its preparation technology was stable and simple.

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