Objective: To optimize vacuum-belt drying process of Fangji Huangqi granules. Method: HPLC was adopted to determine contents of tetrandrine

fangchinoline and astragaloside.With moisture content

total content of tetrandrine and fangchinoline

content of astragaloside as comprehensive evaluating indexes

orthogonal test was used to optimize vacuum-belt drying process of Fangji Huangqi granules with drying temperature

charging rate and belt speed as factors. Result: Optimal vacuum-belt drying process parameters were as follows:temperature of three heated regions at 80

85

80℃

belt speed of 20 cm·min-1

feeding rate of 12 L·h-1

moisture content 4.58%

total content of tetrandrine and fangchinoline 11.97 mg·g-1

content of astragaloside 0.54 mg·g-1. Conclusion: Optimized vacuum-belt drying technology had advantages of high drying rate

good product quality and so on.This study could provide a reasonable basis for industrial production of Fangji Huangqi granules in line with the GMP requirements.