Objective: To prepare Talci Pulvis dispersible tablets and optimized its prescription process. Method: Wtih disintegration time

dispersible uniformity or soft material molding conditions as indexes

excipients species of Talci Pulvis dispersible tablets were screened by single factor tests;With the amount of Talci Pulvis

disintegrating agents and stuffing bulking agents as factors

comprehensive scoring method and D-optimal mixture design were adopted to optimize prescription of Talci Pulvis dispersible tablets by taking disintegration time

dispersible uniformity and suspension stability as indicators. Result: Optimal preparation technology was as following:with microcrystalline cellulose(MCC) as a filler

30% ethanol configured hydroxy propyl methyl cellulose(HPMC) as a binder

cross-linked polyvinylpyrrolidone(PVPP) as a disintegrating agent;The best proportion of prescriptions was Talci Pulvis-MCC-PVPP (0.447:0.400:0.123). Conclusion: Optimized preparation tehcnology was stable and feasible; Established mathematical model of D-optimal mixture design had good predictability which could be used to optimize prescription of Talci Pulvis dispersible tablets.