Objective: To screen out species and amounts of absorption enhancer for intranasal administration preparations of gastrodin. Method: The content of gastrodin was determined by HPLC with mobile phase of acetonitrile-0.05% phosphoric acid(3:97) and detection wavelength at 220 nm.Improved Franz-type diffusion cell was adopted

with rabbit nasal mucosa partition as transdermal barrier

single factor tests were used to compare promoting penetration effect of borneol

propylene glycol and water-soluble azone on intranasal administration preparations of gastrodin

in order to determine kinds and amounts of absorption enhancer. Result: All of three absorption enhancers had promoting penetration effect on intranasal administration preparations of gastrodin

but 5% water-soluble azone was the best one

its cumulative permeation quantity was 3 470.54 μg·cm-2 in 3 h

enhancement ratio was 1.922. Conclusion: 5% Water-soluble azone could be as a absorption enhancer for intranasal administration preparations of gastrodin.