Objective: To investigate the effect of the Jiangtang Xiaoke granule (JTXKG) on the blood glucose and blood lipids in type 2 diabetic rats. Method: Diabetic rats were constructed by high-fat-diet for 4 weeks and combined with intraperitoneal injection of streptozocin 30 mg·kg-1

and the model rats were randomly divided into diabetes model group (T2DM)

positive control group (metformin 0.2 g·kg-1) JTXKG groups with high

medium

and low dose (raw herbs 17.6

8.8

4.4 g·kg-1)

and the normal control group (NC) was also designed. After 4-week treatment

the general condition of rats was observed

and fasting blood glucose (FBG)

blood lipid (BL)

fasting serum insulin (INS)

glycosylated hemoglobin (HbA1c) were tested

glucose tolerance and insulin tolerance were measured. Result: Compared with model group

body weight

FBG and insulin sensitive index levels of JTXKG groups were improved (P<0.05)

HbA1c showed certain changes

but the difference was not statistically significant. However

the serum insulin levels and blood lipid levels did not significantly change. After treatment

the glucose tolerance presents time-related improvement in diabetic rats

the results of insulin tolerance test showed that JTXKG could enhance insulin sensitivity of diabetic rats. Conclusion: JTXKG

the treating principle of which is regulating function of liver spleen and kidney together

can improve glucose and lipid metabolism and pancreatic islet function in type 2 diabetic rats

and relieve insulin resistance that may be the possible mechanism of JTXKG preventing and controlling type 2 diabetes.