Objective: To study the effect of Shuxiong capsule micropowder on whole blood viscosity and the alpha-granular membrane protein(GMP-140) as well as thrombomodulin(TM) content of blood plasma of rats with acute blood stasis. Methold:Sixty rats were randomly divided into six groups as following:the group of Shuxiong capsule micropowder 0.094 5 g·kg-1

the group of Shuxiong capsule micropowder 0.283 5 g·kg-1

the group of shuxiong capsule 0.094 5 g·kg-1

the group of shuxiong capsule 0.283 5 g·kg-1 as well as blank and model groups. After administration for 14 days continuously

acute blood stasis models were replicated by means of epinephrine in ice-bath. Then the effects of shuxiong capsule micropowder on whole blood viscosity and the GMP-140 as well as TM content of blood plasma of model rats were observed. Result: When compared with blank group

the model rats' whole blood low

moderate and high cuts viscosity as well as the GMP-140 and TM content of blood plasma all rise remarkably.Compared with model group

the Shuxiong capsule micropowder and Shuxiong capsule can decreased whole blood viscosity

GMP-140 and TM content of blood plasma. The group of Shuxiong capsule micropowder 0.283 5 g·kg-1 had better effect. Conclusion: The results stated that Shuxiong capsule micropowder can improve blood rheology behavior of rats with acute blood stasis and has remarkable function of activating blood circulation and eliminating stasis. The mechanism might be related to the reduction of the GMP-140 and TM content of blood plasma.