Objective: To observe the curative effect of traditional Chinese medicine oral administration and fumigation on knee osteoathritis after arthroscopy and the influence on tumor necrosis factor α(TNF-α) and interleukin-1β (IL-1β) of synovial fluid. Method: Ninety patients were randomly divided into observation group (n=45) and control group (n=45). Both groups were given arthroscopy. Control group were given conventional western medicine treatment. Observation group were given traditional Chinese medicine oral administration

1 dose each day

for 4 weeks. Traditional Chinese medicine fumigation was added in 5th days of postoperation

2 times each day

for 14 days. Lysholm Knee function score and total symptom score were observed. patients with painful

swelling and joint mobility were in 1

3

7

10

14 day after treatment. The level of TNF-α

IL-1β of synovial fluid were tested. Result: The curative effect of observation group was superior to control group(P<0.01);patients with painful

swelling and joint mobility of both groups in 3 day were significantly improved than before(P<0.01);the degree of improvement of pain

swell and After the treatment of 7

10

14 days joint mobility of observation group was preceded than control group (P<0.01);the lysholm scores of observation group were obviously rison after treatment and higher than control group(P<0.01);total symptom scores of observation group were dramatic declined and lower than control group(P<0.01);the level of TNF-α

IL-1β of synovial fluid of observation group were lower than control group(P<0.01). Conclusion: Traditional Chinese medicine oral administration and fumigation on knee osteoathritis after arthroscopy could improve patients with painful

swelling and joint mobility

promote functional recovery of joint function

enhance clinical effects. The mechanism of action may be related with the level of TNF-α and IL-1β of synovial fluid and is deserved further study.