Objective: Xuefu Zhuyu decoction combined Yueju pill to study the clinical curative effect of add and subtract treatment on stable angina pectoris and its influence on blood lipids. Method: Eighty-six cases of patients were divided into control group (43 cases) and observation group (43 cases) according to the digital method randomly. Patients in both groups took conventional western medicine treatment

simvastatin tablets

20 mg/time

1 time/day. Based on the treatment of control group

patients in the observation group took add and subtract treatment of Xuefu Zhuyu decoction combined Yueju pill

1 dose/day

treatment course 12 weeks. Attack frequency

degree and last time of angina pectoris and the phlegm turbidity syndrome of blood stasis syndrome integral were recorded. Before and after treatment

levels of serum adiponectin (APN)

von willebrand factor (vWF)

hypersensitive c-reactive protein (hs-CRP) were detected. Levels of serum triglyceride (TG)

total cholesterol (TC)

high-density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were also detected. The electrocardiogram of patients was monitored every week. Result: The total effect of electrocardiogram curative effect in observation group (93.0%)was better than control group (76.7%) (P<0.05). The total effect of lipid-lowering effect in observation group (95.3%) was better than control group (79.1%) (P<0.05). After treatment

the levels of blood lipids (TC

TG

LDL-C

HDL-C) of two groups were significantly improved

the improvement of TC and TG in the observation group is better than that of control group (P<0.01). The attack time and duration of angina in observation group were less than the control group (P<0.01).At the eighth and twelfth week after treatment

the phlegm turbidity syndrome score in observation group was lower than the control group (P<0.01). The two groups' level of serum APN were raised

while the observation group was higher than control group (P<0.01). The serum vWF and hs-CRP in both group decreased

the observation group was lower than the control group (P<0.01). Conclusion: Add and subtract treatment of Xuefu Zhuyu decoction combined with Yueju pill can reduce the attack time and duration of stable angina patients

relieving the phlegm turbidity syndrome score. It can also regulate lipid metabolism and improve the electrocardiogram. Its mechanism may be related to regulating APN

vWF

hs-CRP levels in order to reduce inflammation

improving endothelial function.