Objective: The purpose is to study the clinical efficacy and the influences on cellular immune function and angiogenesis correlation factor of Fuzheng Huadu Xiaoai decoction on middle-late stage patients of primary liver cancer. Method: Seventy-two cases of liver cancer patients in middle-late stage were randomly divided into control group and observation group each 36 cases

according to digital method.Two groups were both given symptomatic support treatment:PCB double ester 50 mg/time

3 times/day

treatment course 3 months;Human blood albumin

50 mL/second

1 does/day

7-10 consecutive days when necessary;tramadol hydrochloride zyban

0.1 g/second

take orally when it is necessary

one take not more than 0.4 g Patients in observation group took Fuzheng Huadu Xiaoai decoction 1 dose/day

conventional water frying 2 times/day on the basis of the control group

treatment course 3 months. Serum alpha fetoprotein(AFP) level

peripheral blood T lymphocyte subsets (CD3+

CD4+

CD+

CD4+/CD8+) level

vascular endothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP9) level were measured. Liver function (ALT

AST

TBIL) was monitored. The cardinal symptom

physical sign score

change of life quality (KPS score) and survival rate (6 months and 12 months) were recorded. Result: The effective rate (increasing+stable) of life quality evaluation of the observation group was 86.1%

superior to 58.3% of the control group. The survival rate of 6 months and 12 months of observation group were better than the control group (P<0.05). The serum levels of ALT

AST

TBIL and AFP were lower than the control group (P<0.01).After treatment

the scores of fatigue

nausea and vomiting

pain

insomnia and abdominal distention of observation group were lower than control group (P<0.01). The levels of VEGF and MMP9 in peripheral blood were lower than the control group (P<0.01). The levels of CD3+

CD4+ and CD4+/CD8+ in observation group were higher than the control group

while CD8+ was lower than the control group (P<0.05 or P<0.01). Conclusion: Directed at primary liver cancer patients in middle-late stage

Fuzheng Huadu Xiaoai decoction can relieve the clinical symptoms and signs

improve liver function and the life quality of survival

reduce the levels of AFP

VEGF

MMP9 in peripheral blood and prolong lifetime of survival. Its mechanism may be related to improve patients' immune function and inhibit tumor angiogenesis.