Objective: To discuss the clinical efficacy of Shuanghua Qingwei decoction on patients with chronic periodontitis and the effect on inflammatory factor and pathogenic bacteria. Method: Ninety-six patients were randomly divided into observation group (n=48) and control group (n=48).Both groups were given basic treatment. Control group was given roxithromycin capsules

0.15 g each time

2 times each day;tinidazole tablets

1 g each time

1 times each day. Shuanghua Qingwei decoction were added to observation group

1 decoction each time

2 times each day

all for 7 days. Local symptoms of periodontal were observed

including the gingival index(GI)

plaque index(PLI)

pocket depth(PD)

sulcus bleeding index(SBI)

tumor necrosis factor-α(TNF-α)

prostaglandin E2(PGE2)

interleukin count-6(IL-6). Polymerase chain reaction was used to test pathogenic bacteria

including actinobacillus actinomycetemcomitans(Aa)

porphyromonas gingivalis aeromonas(Pg)

bacteroides forsythus(Tf). Result: The total effective rate of observation group (91.7%) was superior to control group (75.0%) (P<0.01);the scores of SBI

PLI

GI in observation group were lower than control group (P<0.01);the level of TNF-α

PGE2

IL-6 in observation group were lower than those in control group (P<0.01);the relevance ratio of Aa

Pg

Tf in observation group were lower than those in control group (P<0.01). Conclusion: Shuanghua Qingwei decoction can control inflammation level of CP patients

inhibit the content of periodontal pathogen

relieve the clinical symptoms of disease

enhance curative effect. It is worthy of clinical use.