Objective: To observe the curative effect of Bushen Shugan decoction on mild to moderate level of depression in Parkinson disease (PD)with liver and kidney yin deficiency. Method: One hundred and nine PD patients were randomly assigned to the treated group and the control group. Both were treated according to the international medication guiding principle for PD treatment

and the treated group was administered with Bushen Shugan decoction additionally. The treatment course lasted for 9 consecutive months

and the end point was the end of the 9th month. The scores of unified Parkinson's disease rating scale (UPDRS)

Hamilton depression rating scale (HAMD)

activities of daily living (ADL) and liver and kidney yin scale of traditional Chinese medicine (TCM) were evaluated before treatment

every 3 months of the treatment and at the end point. Result: After treatment

UPDRS total scores and ADL scores in both groups showed a significant ascending trend at a slower rate in the treated group than in the control group;At the end point

the scores in the treatment group were lower than the control group

there was a significant difference between the two groups (P<0.05 or P<0.01). After treatment

HAMD scores in both groups showed an descending trend in both groups

but there was no significant difference between the two groups at the same period. After treatment

the TCM scores decreased in the treatment group while increased in the control group;At the end point

the TCM scores in the treatment group were much lower than the control group

there was a significant difference between the two groups (P<0.01). Conclusion: The recipe for Bushen Shugan decoction could improve the motor and depressive symptoms

as well as the liver and kidney yin deficiency symptoms of traditional Chinese medicine

which could enhance PD patients' activities of daily life.