Objective: To investigate effects of pharmaceutical excipients on moisture absorption of total flavonoids from Ilex pubescens. Method: Moisture absorption percent of total flavonoids from I. pubescens was determined by powder moisture absorption method;Taking initial velocity of moisture absorption

moisture absorption accelerated speed

equilibrium moisture absorption time

equilibrium hygroscopicity

critical relative humidity and others parameters as indexes

effects of pharmaceutical excipients on moisture absorption of total flavonoids from I. pubescens were investigated. Result: The critical relative humidity of total flavonoids from I. pubescens was 78.1%

and it was increased by lactose

magnesium stearate

talc powder and calcium hydrogen phosphate.Moisture absorption process and equilibrium hygroscopicity of samples all accelerated treating by some excipients in order of PVPP>CMS-Na>croscarmellose sodium>dextrin>starch;Moisture absorption accelerated speed and equilibrium hygroscopicity of samples all reduced to different degrees treating by other excipients in the order of calcium hydrogen phosphate>talc powder>lactose>magnesium stearate>aerosil>MCC. Conclusion: Rational usage of excipients could improve moisture absorption and stability of total flavonoids from I. pubescens.