Objective: To optimize formulation process of matrine gels and evaluate its in vitro release characteristics. Method: The content of matrine was measured by HPLC

mobile phase of acetonitrile-0.02 mol·L-1 potassium dihydrogen phosphate solution(6:94)

detection wavelength 210 nm.Dynamic dialysis method was adopted to determine in vitro release rate of matrine gels

taking composite score of cumulative release rates at 1

5

10 h as index

orthogonal test was applied to optimize formulation process with amounts of carbomer-940

matrine and azone

gels pH as factors. Result: Optimized formulation process of matrine gels was obtained

dosages of carbomer-940

matrine and azone were 1.0

2.0

0.5 g

respectively;Gels pH was adjusted to 6.8 eventually.In vitro cumulative release rate at 1

5

10 h were(10.17±0.35)%

(74.90±0.70)% and (94.53±0.74)%

respectively. Conclusion: This optimized process was simple and feasible

these prepared matrine gels had sustained release properties.