Objective: To study the effects of Simo decoction on expression of secretin(Sec) and substance P(SP) in cold-constraint stressed mice

and to explore the mechanism of Simo decoction(SD) on functional gastrointestionl disorders(FGIDs). Method: Gastrointestinal dysfunction model was established by exerting the factors of cold-constraint stimulation. And then randomly treated with distilled water

Dicetel(20.3 mg·kg-1) and SD at dosage of 1.8

0.9 g·kg-1were given

for continuous 14 days. The content change of Sec and SP in serum was tested by ELISA. The expressions of Sec and SP in brain tissue were measured by immunohistochemical staining. Result: The expressions of Sec in brain and serum of model group were decreased

and SP in model group was increased

compared with the normal group(P<0.01).The SD could increase the expression of Sec in brain tissue and serum

and reduce the expression of SP

which also had significant differences compared with the model group(P<0.05 or P<0.01). There was remarkable difference between SD high and low-dose group(P<0.05). Conclusion: Simo decoction can regulate the expression of Sec and SP in cold-constraint stressed mice

which is one of possible mechanism.