Objective: To evaluate the curative effect and side-reactions of Bufei Xiaoji decoction in the treatment of patients with advanced drugs-resistant non-small cell lung cancer (NSCLC). Method: A total of 228 cases who suffered from failed treatment by first-line chemotherapy and possessed Qiyinl and phlegm stasis symptom were randomly divided into control group (114 cases) and treatment group (114 cases) from Ruikang hospital affiliated to Guangxi university of Chinese medicine. The control group accepted second-line chemotherapy for four weeks as a cycle

lasted two cycles. The treatment group was given Bufei Xiaoji decoction on basic treatment

for 4 weeks as a cycle

lasted two cycles. Result: One hundred and ninty-seven patients indicated clinical efficacy. In treatment group efficiency

the improvement rate of traditional Chinese medicine(TCM) symptom

CEA and CYFRA21-1 levels decreased

Ⅱ-Ⅳ degree white blood cell(WBC) and hemoglobin(HGB) reduced

gastrointestinal reactions

kidney damage incidence and one-year survival rate was superious to the control group (P<0.05);In Ⅱ-Ⅳ degree of thrombocytopenia and liver damage

there was no differences. Conclusion: Bufei Xiaoji decoction can improve the quality of life of the advanced drugs-resistant NSCLC

and enhance the clinical efficacy of chemotherapy and reduce chemotherapy toxicity

which suggests that Bufei Xiaoji decoction may have advantage in the reversal of lung tumor multidrug resistance.