Objective: To discuss the effect of Penyanping decoction plus Pudi decoction on the immunoregulation of patients with chronic pelvic inflammatory disease (hot and damp stasis junction). Method: One hundred and twenty patients were randomly divided into observation group(n=60) and control group(n=60). Control group was given Huangtengsu dispersible tablets after menstrual clean

4 tablets each time

3 time each day

for 20 days

matrine suppositories

1 capsule each time

1 time each day after menstrual clean for 3 days

for 20 days. Observation group was given Penyanping decoction after menstrual clean

200 mL each dosage

1 dosage each day

all for 20 days

Pudi decoction

1 dosage each day after menstrual clean for 3 days

for 10 days. Both groups were observed for 3 menstrual cycle. Immune globulin G

immune globulin A

immune globulin M(IgG

IgA

IgM) of pretherapy and post-treatment were tested by rate nephelometry. Complement in blood serum(complement-C3

complement-C4) were measured by Single radil immunodiffusion. T lymphocyte subtype of CD3+

CD4+

CD8+ and CD4+/CD8+ were detected by flow cytometry. The level of interleukin-2

interleukin-10

tumor necrosis factor-α(IL-2

IL-10

TNF-α)were tested. Result: The cases of abnormal IgG

IgA

IgM

C3 and C4 in observation group were less than control group(P<0.05)

the level of IgG

IgA

IgM of both groups after the treatment were lower than before

and the level of C3

C4 of both groups were higher than before(P<0.05 or P<0.01). The level of IgG in observation group were lower than control group

and the level of C3

C4 in observation group were higher than control group(P<0.05 or P<0.01). The cases of abnormal CD3+

CD4+

CD8+

CD4+/CD8+ in observation group were less than control group(P<0.05)

the level of CD3+

CD4+

CD4+/CD8+ in observation group were higher than control group

the level of CD8+ in observation group were lower than control group(P<0.05 or P<0.01). The level of IL-2

IL-10 of both groups were risen

and observation group were higher than control group

the level of TNF-α of both groups were declined

and observation group were lower than control group(P<0.01). Conclusion: Penyanping decoction plus Pudi decoction can adjust humoral immunity

regulate T lymphocyte subtype and the level of inflammatory cytokines

promote equilibrium so as to be benefitial for disease rehabilitation. It may be significant mechanism of action.