Objective: To optimize forming process of Dantao granules. Method: With ratio of soluble starch-dextrin

excipients consumption and ethanol concentration as independent variables

yield of qualified granules

dissolubility and critical relative humidity as dependent variables

forming process of Dantao granules was optimized by central composite design-response surface methodology and overall desirability method. Result: Optimal molding technology conditions were as follows:quality ratio of excipients-extract powder (2:1)

proportion between starch-dextrin (1:1)

with 75% ethanol as wetting agent;yield of qualified granules was about 85%

melting time was less than 1 min

critical relative humidity was about 58%. Conclusion: Optimized molding process was stable and reliable with high qualified rate

good dissolubility and strong anti-hygroscopicity

this research could provide basis for preparation and production environmental control of Dantao granules.