星点设计-效应面法优选穿心莲提取物--环糊精包合物制备工艺

刘玲; 李小芳; 文怡静; 舒予; 吴珊; 罗丽佳

doi:10.11653/syfj2014020022

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星点设计-效应面法优选穿心莲提取物--环糊精包合物制备工艺

更新时间：2024-01-04

- 星点设计-效应面法优选穿心莲提取物--环糊精包合物制备工艺
- Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology
- 中国实验方剂学杂志 2014年20卷第2期页码：22-25
- 作者机构：
- 作者简介：
- 基金信息：
  
  四川省教育厅重点项目（12ZA042）
- DOI：10.11653/syfj2014020022
  中图分类号：
- 纸质出版日期：2014
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刘玲, 李小芳, 文怡静, 等. 星点设计-效应面法优选穿心莲提取物--环糊精包合物制备工艺[J]. 中国实验方剂学杂志, 2014,20(2):22-25.

LIU Ling, LI Xiao-fang, WEN Yi-jing, et al. Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 22-25.
刘玲, 李小芳, 文怡静, 等. 星点设计-效应面法优选穿心莲提取物--环糊精包合物制备工艺[J]. 中国实验方剂学杂志, 2014,20(2):22-25. DOI： 10.11653/syfj2014020022.

LIU Ling, LI Xiao-fang, WEN Yi-jing, et al. Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 22-25. DOI： 10.11653/syfj2014020022.

摘要

目的：采用星点设计-效应面法优化穿心莲提取物-β-环糊精（β-CD）包合物的制备工艺。方法：采用超声法制备穿心莲提取物-β-CD包合物，以包合率为评价指标，采用星点试验考察β-CD与穿心莲提取物的投料质量比、包合时间及包合温度对包合工艺的影响，对试验数据进行多元线性回归和二项式方程拟合，通过效应面法优选包合工艺条件并进行验证试验。结果：最佳包合工艺条件为β-CD与穿心莲提取物的投料质量比5.57：1，包合时间4.5 h，包合温度55 ℃；包合率预测值与理论值的偏差1.18%。结论：星点设计-效应面法适用于优化穿心莲提取物-β-CD包合物的制备工艺，建立的数学模型具有良好的预测性。

Abstract

Objective: To optimize preparation technology of Andrographis Herba extract-β-cyclodextrin(β-CD) inclusion complex by central composite design and response surface method. Method: Andrographis Herba extract-β-CD inclusion complex was prepared by ultrasonic method.Taking inclusion rate as index

central composite design test was adopted to optimize inclusion process with mass ratio of Andrographis Herba extract and β-CD

inclusion time and inclusion temperature as factors

test data were fitted by multi-linear equation and second-order polynomial equation

optimal inclusion technology was predicted by response surface method. Result: Optimum inclusion technology were as follows:mass ratio of Andrographis Herba extract and β-CD 5.57:1

inclusion time 4.5 h

inclusion temperature 55 ℃;Deviation between the observed value and the predicted value was 1.18%. Conclusion: Central composite design and response surface method was suitable for optimizing preparation technology of Andrographis Herba extract-β-CD inclusion complex

this established mathematical model had good predictability.

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