Objective: To optimize extraction technology of modified Sijunzi decoction. Method: Taking total extraction amounts of ginsenoside as index

L9(34) orthogonal design was adopted to optimize alcohol extraction technology of Ginseng Radix et Rhizoma

Atractylodis Macrocephalae Rhizoma and Paeoniae Radix Alba with ethanol amount and concentration

extraction time and times as factors;With yield of total polysaccharides as index

L9(34) orthogonal design was used to optimize water extraction technology of Poriae Cutis

Hedyotidis Herba and Glycyrrhizae Radix et Rhizoma by taking solid-liquid ratio

extraction time and times as factors.The content of ginsenoside was determined by HPLC

mobile phase of acetonitrile-water(13:87)

detection wavelength 203 nm;UV was adopted to measure the content of polysaccharides with detection wavelength at 489 nm. Result: Optimum alcohol extraction process was as following:extracted twice with 6 times the amount of 70% ethanol for 1.5 h per time;Extraction amount of ginsenoside was up to 7.69 mg·g-1.Optimum water extraction process was:extracted three times with 8 times the amount of water for 2 h each time;Yield of total polysaccharides reached 2.18%. Conclusion: This optimized extraction technology was stable and feasible

it could full extract alcohol-soluble and water-soluble active ingredients from modified Sijunzi decoction.