Objective: To observe the effects of Rhizoma Zingiberis

Cortex Cinnamomi

Syzygium aromaticum

Fructus Evodiae

Fructus Foeniculi

Rhizoma Alpiniae Officinarum

Fructus Piperis Longi

Piper cubeba

Pericarpium Zanthoxyli

Fructus Piperis Nigri

the ten herbs of warming middle-jiao and dispelling cold on the pathologic tissues of gastric mucosa in rats with stomach excess cold syndrome

and research the warming and protective effect on stomach. Method: SD male rats were divided into 15 groups:blank group

model group

Radix Aconiti Lateralis Preparatax group

Rhizoma Zingiberis group

Cortex Cinnamomi group

Syzygium aromaticum group

Fructus Evodiae group

Fructus Foeniculi group

Rhizoma Alpiniae Officinarum group

Fructus Piperis Longi group

Piper cubeba group

Pericarpium Zanthoxyli group

Fructus Piperis Nigri group

Gypsum Fibrosum group and Rhizoma Coptidis group.the stomach cold syndrome model in rats was established by water extract of Rhizoma anemarrhenae 17.5 g·kg-1

twice per day

lasting two days. the dosage of Radix Aconiti Lateralis Preparatax group was 13.5 g·kg-1

the dosage of Rhizoma Zingiberis and Fructus Piperis Nigri group was 8.1 g·kg-1

the dosage of Cortex Cinnamomi and Fructus Evodiae group was 4.1 g·kg-1

the dosage of Fructus Caryophylli and Fructus Piperis Longi

Piper cubeba group was 2.7 g·kg-1

the dosage of Fructus Foeniculi

Rhizoma Alpiniae Officinarum and Pericarpium Zanthoxyli group was 5.4 g·kg-1

the dosage of Gypsum Fibrosum group was 54 g·kg-1

the dosage of Rhizoma Coptidis group was 4.5 g·kg-1

twice per day in 3 times. The changes of the gastric mucosa were observed by naked eyes and th echanges of pathological section were observed by light microscope

and graded according score criterion of the pathologic tissues of gastric mucosa. Result: Compared with blank group

the stomach mucous membrane in model group had dark color

crimple

hemorrhagic spots and no gloss

compared with model groupthe stomach mucous membrane in the 10 treatment groups was improved.All the treatment groups could significantly decrease the imflammatory cells infiltration(P<0.05 or P<0.01)except the group of Alpinia group and reduce the glands(P<0.01). Conclusion: The ten herbs with warming middle-jiao and dispelling cold have good improvement on the pathologic tissues of gastric mucosa so as to treat stomach cold syndrome.