Objective: To discuss the effects of traditional Miao national herbs Sidaxue on rheumatoid arthritis and its mechanism. Method: An animal model of adjuvant arthritis (AA) was established

rats were divided into blank control group

model control group

high dose Sidaxue treatment group

middle dose Sidaxue treatment group

low dose Sidaxue treatment groups

positive control group(glucosidorum tripterygll totorum control group). The rat paw edemas of rats was measured;Synovial cells were primarily cultured

and the 3rd generations of subculture cell were adopted for experiment. Western-blotting method was adopted to detect the protein expression level of B cell lymphoma/leukemia-2(Bcl-2)

Bcl-2 associated X protein(Bax). Result: Miao national herbs Sidaxue could inhibit the swelling of paw (P < 0.05);decrease the protein expression of Bcl-2 (P < 0.05

P < 0.01)

increase the protein expression of Bax in Arthritis rats' synoviocyte(P < 0.01)

and decrease the rate of Bcl-2/Bax. Conclusion: Miao national herbs Sidaxue can antagonize the development of AA

the mechanism of which may be related to promoting apoptosis of synoviocyte.