Objective: To investigate the changes of inflammatory cytokines

renal vascular endothelial function in early diabetic nephropathy and the effect of salvianolate on intervention.Method: Sixty-four patients with early diabetic nephropathy were selected and randomly divided into 2 groups(routine group and salvianolate group).routine group was treated with insulin;the salvianolate group was treated with 200 mg·d-1 salvianolate combined with insulin. 30 healthy as control group.The endothelium-dependent flow-mediated dilatation(FMD)of brachial artery was determined with ultrasound

and the levels of soluble intercellular adhesion molecule-1(sICAM-1)

endothelin-1(ET-1)

interleukin-6(IL-6)

tumor necrosis factor(TNF-α)and High-sensitivity C-reactive protein(hs-CRP)were measured respectively before and after treatment. Result: All patients with early diabetic nephropathy showed that the hs-CRP

TNF-α

IL-6

ICAM-1 and ET-1 was higher than that of the controlled group(P<0.05)

the FMD were lower than controlled group(P<0.05). After treatment the hs-CRP

TNF-α

IL-6

ICAM-1 and ET-1 in the salvianolate group[hs-CRP(9.24±2.16)mg·L-1

sICAM-1(257.72±16.32) μg·L-1

ET-1(103.78±12.21) ng·L-1

TNF-α(14.62±7.23) ng·L-1

IL-6(16.12±5.68) ng·L-1]was decreased more significantly than routine group[(14.58±3.32)mg·L-1

(567.43±16.24) μg·L-1

(258.5±9.78) ng·L-1

(36.72±6.23)ng·L-1

(34.62±7.01)ng·L-1](P<0.05). After treatment the FMD in the salvianolate group was increased more significantly than routine group[(10.12±3.27)% vs(7.17±0.32)%](P<0.05). Conclusion: The salvianolate can effectively reduce the bodys inflammationrecovery and recovery renal vascular endothelial function with early diabetic nephropathy.