Objective: To prepare Apocyni Veneti Folium pulse compression-coated tablets. Method: Apocyni Veneti Folium pulse tablets were prepared by dry-compression technique with release lag-time and accumulated release rate in 7 h as evaluation indexes

Box-Behnken design was adopted to investigate effects of ratio of CMS-Na to mannitol in core tablet

hydrogenated castor oil to PEG6000 in coating film and coating weight to core weight on prescription process

functional relationship between indexes and factors was established by binomial equation

prescription of Apocyni Veneti Folium pulse compression-coated tablet was optimized by response surface methodology

and optimized prescription for verification. Result: Relationship between indexes(lag-time and accumulated release rate in 7 h) and factors were fitted by binomial equation

regression coefficients of them were 0.979 8 and 0.955 4

respectively.Optimum prescription was as follows:CMS-Na to mannitol(1:1)

hydrogenated castor oil to PEG6000(5.38:1) and coating weight to core weight(1:1);Under these conditions

in vitro lag-time of these prepared tablets was about 5 h

then drug released from these tablets within 6-8 h was found to conform to zero-order kinetics and controlled by bulk erosion mechanism.Bias between observed values and predicted values of lag-time and cumulative release rate in 7 h were 3.61% and-1.42%

respectively. Conclusion: These prepared Apocyni Veneti Folium pulse compression-coated tablets had an ideal timing pulse release effect.