Objective: To study the effect of high-temperature heat treatment of Psoralea corylifolia on the activity of tyrosinase. Method: The activity of tyrosinase was detected by measuring the oxidation rate of L-DOPA in vitro. Result: In addition to the low concentration and median concentration in the 30 min

in the same concentration and high-temperature heat time

the higher the temperature was more

the stronger the activation rate on tyrosinase would be. In the same concentration and temperature

the activation rate was not regularly increased or decreased with the increase of heating time. When the mass concentration was 2 g·L-1

and heated treatment 40 min and 20 min at 121 ℃

the activation rate on tyrosinase was the highest

135.45%±4.29% and 106.97%±3.21% respectively. Conclusion: By controlling appropriate temperature and time

P. corylifolia could enhance the activation of tyrosinase activity.