Objective: To research the effects of Zhali Nusi fang(ZLNSF) on the permeability changes of blood brain barrier after focal cerebral ischemia-reperfusion in rats. Method: SD rats were divided randomLy into Sham-operated

model

nimodipine and ZLNSF groups. Rat focal cerebral ischemia-reperfusion model was established by middle cerebral artery occlusion with nylon thread.Afte rats were administered orally with corresponding drugs 1

3

7

14 d

then take out brain.The neurological scores were evaluated.Wet and dry weight measured brain water content;immunohistochemical method to measure IgG expression. Result: Compared with the Sham-operated group

ischemia reperfusion brain water content

IgG expression was significantly increased (P < 0.01

P < 0.05)

neurological function score significantly dropped (P < 0.01);compared with the model group

the nimodipine group of brain water content

neurological function score emerged varying degrees of improvement (P < 0.05)

the expression of IgG level decreased

especially in 3

7 d significantly (P < 0.01);compared with nimodipine group

ZLNSF group brain water content

IgG expression was emerged varying degrees down (P < 0.05)

and nerve function integral increases especially in 3

7 d;compared with 1 d

ZLNSF 3

7 d groups the expression of IgG levels were significantly lower (P < 0.05). Conclusion: Cerebral ischemia-reperfusion injury can induced breakdown and increased permeability of the blood-brain barrier after 1-7 d

then the blood-brain barrier permeability gradually restored after seven days;it is indicated that the treatment of the ZLNSF can promote the cerebral protection. Its mechanism may be related to down-regulate the expression of IgG and reduce the permeability of blood-brain barrier

hold back harmful and large molecules from entering the brain

which plays a critical protective effect.