Objective: To investigate the clinical research and effects on microcirculation of self defense Tongqiao decoction to treatment with sudden deafness. Method: One hundred and twenty cases of patients with sudden deafness were randomly divided into control group(n=60)and observation group(n=60). Control group were treatmented with alprostadil injection of 10 μg/times

intravenous infusion

1 time each day; methylcobalamin tablets

500 μg orally

3 times/d. Observation group were treatmented with additional services Tongqiao decoction

and add or subtract according to different syndromes

1 time each day. Treatment lasted 14 d. The changing circumstances of pure tone threshold were measured with acoustic impedance and pure tone audiometry. The hemodynamics were detected in patients before and after treatment. The improve time of hearing

tinnitus

vertigo

ear fullness were record.The levels of plasma endothelin (ET)

serum nitric oxide (NO) were treatmented with radioimmunoassay detected. Result: The total effective rate of mild to moderate hearing (95.15% vs 84.2%) was higher than severe hearing.The average total effective rate of observation group(91.66% vs 77.5%)were better than the control group (77.5%

55.0%

and 70.0%) (P<0.05);the pure tone hearing thresholds after 7 and 14 days were improved than before treatment.The observation group were impoved than the control group (P<0.01).The hemodynamic parameters after treatment were significantly improved

The levels of fibrinogen (Fb)

low shear rate whole blood viscosity were improvement than the control group (P<0.01);The levels of ET and NO of observation group were higher than control group (P<0.01). Conclusion: Tongqiao soup dialectical treatment of sudden deafness can reduce clinical symptoms

improve listening skills

improve clinical efficacy.Its mechanism may be related to the decrease in patients with blood viscosity

increased inner ear blood flow

improve microcirculation inner ear.