Objective: Observation of warming the kidney and strengthening the spleen Huazhuo oral and Enema of dialectical therapy for stage 3 chronic kidney disease (CKD3) clinical curative effect. Method: Eighty-four cases of CKD3 were randomly divided into control group and study group

each of 42 cases. Two groups were treated with lifestyle intervention

symptomatic treatment. Observation group added the application of warming the kidney and strengthening the spleen Huazhuo prescription

including traditional Chinese medicine(TCM) and syndrome was given Huazhuo prescription enema. Treated for 4 months. Record of blood urea nitrogen (BUN)

serum creatinine (Scr)

glomerular filtration rate (GFR)

uric acid (UA)

24 h urinary protein (Upr)

serum albumin (Alb)

triglyceride (TG)

total cholesterol (TC)

red blood cell count (RBC)

hemoglobin (Hb) changes the main symptoms

physical signs score record. Result: The curative effect to total efficiency in study group was 71.4%

more than that of control group 47.6% (P<0.05); the curative effect of TCM syndrome group total effective rate in study group was 78.6%

more than 57.1% of control group (P<0.05);Scr in study group was decreased compared with that before treatment

and lower than that of the control group (P<0.01);control group Upr continued to rise

the study group Upr decreased after treatment

the study group than in the control group (P<0.01);study group UA decreased

and lower than that of the control group (P<0.01);control group eGFR continued to decline

after the treatment were observed in group eGFR than that in the control group (P<0.05);the observation group TG and TC were decreased than that before treatment

and lower than that of the control group (P<0.05). Conclusion: The treatment of warming the kidney and strengthening the spleen Huazhuo prescription after 4 months improved renal function in CKD3 patients

alleviate the clinical symptoms

delay the progress of CKD3 phase

which is worthy of clinical use.