Objective: To systematically review the effectiveness and safety of Qishen Yiqi dropping pills for ischemic heart failure. Method: Randomized clinical trials concerning Qishen Yiqi dropping pills for ischemic heart failure were searched through CNKI

VIP

WANFANG

PubMed

the Cochrane library from inception to 2013 February. The qualities of included trials were evaluated with the tool of Cochrane method for intervention and the meta-analyses were performed with RevMan5.0.2 software. Result: Ten trials involving 1 070 patients were included. The results of Meta-analyses showed that the combination of Qishen Yiqi dropping pills and western medicine therapy could effectively improve the left ventricular ejection fraction [WMD=0.07

95%CI(0.05

0.08)

P<0.000 01] and increase the six-minute walking distance [WMD=48.31

95%CI (39.51

57.10)

P<0.000 01]

with significant differences compared with the simple western medicine treatment. Qishen Yiqi dropping pills could lower the level of B-type natriuretic peptide. Conclusion: Qishen Yiqi dropping pills could improve the heart function in patients with ischemic heart failure. However

due to the small scale and low quality of included RCT

there was not enough evidence for the popularization and application of Qishen Yiqi dropping pills.