基于指标成分和药效学优选肠康颗粒的醇沉工艺

华俊磊; 丁永芳; 陆敏; 沈明勤; 鞠建明; 李松林; 李振华

doi:10.11653/syfj2014040016

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基于指标成分和药效学优选肠康颗粒的醇沉工艺

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- 基于指标成分和药效学优选肠康颗粒的醇沉工艺
- Optimization of Alcohol Precipitation Technology of Changkang Granules Based on Index Components and Pharmacodynamics
- 中国实验方剂学杂志 2014年20卷第4期页码：16-19
- 作者机构：
- 作者简介：
- 基金信息：
  
  江苏省科技支撑计划——社会发展项目（BE2012776）;江苏省中医药研究院新药研发项目（Y1206）
- DOI：10.11653/syfj2014040016
  中图分类号：
- 纸质出版日期：2014
- 稿件说明：
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华俊磊, 丁永芳, 陆敏, 等. 基于指标成分和药效学优选肠康颗粒的醇沉工艺[J]. 中国实验方剂学杂志, 2014,20(4):16-19.

HUA Jun-lei, DING Yong-fang, LU Min, et al. Optimization of Alcohol Precipitation Technology of Changkang Granules Based on Index Components and Pharmacodynamics[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 16-19.
华俊磊, 丁永芳, 陆敏, 等. 基于指标成分和药效学优选肠康颗粒的醇沉工艺[J]. 中国实验方剂学杂志, 2014,20(4):16-19. DOI： 10.11653/syfj2014040016.

HUA Jun-lei, DING Yong-fang, LU Min, et al. Optimization of Alcohol Precipitation Technology of Changkang Granules Based on Index Components and Pharmacodynamics[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 16-19. DOI： 10.11653/syfj2014040016.

摘要

目的：优选肠康颗粒的醇沉工艺并从药效学角度考察醇沉工艺的合理性。方法：以除杂率和金丝桃苷、盐酸小檗碱、芍药苷、升麻素苷含量的综合评分为指标，通过单因素试验考察醇沉浓度和清膏相对密度对醇沉工艺的影响，采用小鼠肠推进试验比较肠康颗粒水提清膏醇沉前后的药效。结果：最佳醇沉工艺条件为提取液浓缩至相对密度1.13（70 ℃）的清膏，加95%乙醇醇沉含醇量85%。结论：优选的醇沉工艺达到了较好的去杂效果并充分保留了药效，为水提醇沉工艺的科学性提供实验依据。

Abstract

Objective: To optimize alcohol precipitation technology of changkang granule

and investigate rationality of alcohol precipitation technology by pharmacodynamics. Method: With impurity removal rate and contents of multi-component(hyperoside

berberine

paeoniflorin and prim-O-glucosylcimifugin) as comprehensive evaluation index

single-factor tests were used to optimize alcohol precipitation technology by taking the concentration of alcohol precipitation and relative density of extract as factors

efficacy of water extract before and after alcohol precipitation was compared through intestinal propulsion test of mice. Result: Optimum alcohol precipitation process was as follows:concentrated extracting liquid to relative density of 1.13(70 ℃)

added 95% ethanol until the concentration of ethanol to 85%. Conclusion: Good impurity cleaning effect was obtained by optimized alcohol precipitation technology and efficacy was fully kept

it provided experimental basis for scientificity of water extraction-alcohol precipitation technology.

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