Objective: To optimize extraction technology of total phenolic acids and chlorogenic acid from Inulae Radix. Method: With extracting amounts of total phenolic acids and chlorogenic acid as indexes

based on single factor tests

orthogonal test was adopted to optimize microwave-assisted extraction technology by taking extraction time

ethanol concentration

solid-liquid ratio and extraction temperature as factors.The content of total phenolic acids was determined by UV;HPLC was adopted to determine the content of chlorogenic acid with mobile phase of acetonitrile-0.4% phosphoric acid(13:87) and detection wavelength at 327 nm. Result: Optimum extraction conditions were as follows:ethanol concentration of 35%;extracted 5 minutes with solid-liquid ratio of 1:23

extraction temperature at 75 ℃;Under these conditions

extracting amounts of total phenolic acids and chlorogenic acid were (6.78±0.19) and (1.53±0.09) mg·g-1

respectively. Conclusion: Optimized microwave-assisted extraction process was effective with low energy consumption

which was suitable for industrial production.