Objective: To optimize water extraction process of Yixin Tongmai mixtures. Method: With contents of salvianic acid A sodium and calycosin-7-glucoside

yield of dry extract as indexes

L9(34) orthogonal test was adopted to investigate effects of the amount of water

decocting time and times on extraction technology.HPLC was adopted to determine contents of salvianic acid A sodium and calycosin-7-glucoside with detection wavelength of 280 and 260 nm

respectively. Result: Effects of each factors on water extraction technology was in order of decocting times >the amount of water >extracting time

optimal extraction conditions were as follows:decocted 3 times with 15-fold water

0.5 h each time;Under these conditions

average extracting amounts of salvianic acid A sodium and calycosin-7-glucoside were 4.928 and 0.399 5 mg·g-1

respectively. Conclusion: Optimized extraction process was stable and feasible

which was suitable for standardization production of Yixin Tongmai mixtures.