OUYANG Xi-lin, ZHU Zhi-ren, PAN Ying-ming. Synthesis, Characterization and DNA-binding Properties of Co(Ⅱ) Complex of Kaempferitrin[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 49-53.
OUYANG Xi-lin, ZHU Zhi-ren, PAN Ying-ming. Synthesis, Characterization and DNA-binding Properties of Co(Ⅱ) Complex of Kaempferitrin[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 49-53. DOI: 10.11653/syfj2014040049.
Objective: To synthesize and characterize a Co (Ⅱ) complex of kaempferitrin and to perform its interaction with DNA. Method: A Co (Ⅱ) complex of kaempferitrin was synthesized and characterized by elemental analysis
IR
TG-DTG and ESI-MS. The interactions of the Co (Ⅱ) complex and kaempferitrin with DNA were investigated by UV-Vis
fluorescence spectra and CD spectra. Result: Experimental results indicated that Co (Ⅱ) complex and kaempferitrin can both bind to DNA by intercalation modes
but the binding affinity of Co (Ⅱ) complex is much higher than that of kaempferitrin. Conclusion: KR-Co (Ⅱ) complex with DNA interactions was stronger than KR
suggesting KR-Co (Ⅱ) complex with greater activity than KR.